a european community on targeted therapy in renal cell cancer using genetic and tumour-related biomarkers for response and toxicity I can’t remember seeing

a title with more than one colon in a carefully edited publication In the revised example above, the colon indicates that what follows it elaborates on what precedes it. In the recast, you can use “using” without the second colon in your title.

I can’t explain new example but thanks @sven.

This question slightly obliquely addresses this question by limiting its style advice to what it refers to “two subtitles” within a title. After asserting (at 14 as of June 15): Assuming this is an asserting. It has been found that “A colon, also italicized, is used to separate the main title from the subtitle.” Chicago addresses the situation where a single title appears to have

two subtitles: 14. A total of 1998 2 subtitles, also in English to avoid confusion. If, as occasionally happens, there are two subtitles in the original (an awkward contingency), a colon normally follows the first and a semicolon the second. Is it necessary to click on a subline? Both begin with capital. *

Who is Serena and what is Gitta? Why children kill; The Story of Mary Bell. New York: Metropolitan Books, 1999. (No. ed.)

Although Chicago explicitly frames this advice as a way to handle such titles in a bibliography, there is nothing special about bibliographies that would forbid double colons there but not in regular text.

Chicago doesn’t explain its dislike of double colons in public – but I suspect that the hostility arises involves the absence of clear hierarchical subordination that arises from a title rendered as X: Y: Z. Does the colon after Y represent that Z is a subtitle of X and a subsubtitle of Y? The colon/semicolon form X: Y; X indicates rather more clearly that Y and Z are on an equal footing as subtitles of X —just as in a list, where “the following: X ; Y ; Z ” clearly marshals hierarchically equal-status entries X, Y, and Z. In contrast, “the following: X : Y : Z” is (by normal conventions of punctuation) fatally ambiguous with regard to hierarchical meaning.

How much will the Chicago style recommendation extend the subject, and

how will it affect the title you write? Description of the eurotarget cohort: A european collaborative project on targeted therapy in renal cell cancer; Genetic

and tumour related biomarkers for response and toxicity With regard to g whether the G in Genetic should remain capped, Chicago advises simply that titles with sentence-style capitalization should begin “a subtitle” with an initial cap; it doesn’t consider whether the subtitle in question is the only one, the

first or the second of two: What is sentence style capitalization? In sentence style capitalization only the first words in a title, the first word in a subtitle, and any proper names are capitalized. I

can conclude from a piece your example that Chicago would approve of a G in Genetics (or

the originals which don’t).