a european community on targeted therapy in renal cell cancer using genetic and tumour-related biomarkers for response and toxicity I can’t remember seeing

a title with more than one colon in a carefully edited publication In the revised example above, the colon indicates that what follows it elaborates on what precedes it. In the recast, you can use “using” without the second colon in your title.

I can’t explain new example but thanks @sven.